Settle in with history, with a stay at the former home of Constitution signer and statesman John Rutledge. Exteriors boast intricately detailed wrought-iron balconies; the interiors are complete with canopy beds and antique decor. Breakfast is served in the courtyard, afternoon tea on the piazza, and a glass of port, sherry, or brandy of your choosing at the Inn in the evening.

Mills House is pretty in pink. The current building, a 1970s replica of the original 1863 hotel, houses 210 simple yet pristine rooms, plus a killer courtyard pool. If you just so happen to be nursing a hangover and bristle at the thought of stepping out into the southern sunshine, Lowcountry classics like she-crab soup and local shrimp with Carolina gold rice are just a bell away.